
The US used laser guided weapons in combat during Desert Storm. They were mounted to both blast fragmentation and penetrator bodies. The historical record is full of photos of demolished harden aircraft shelters and other structures that received hits from BLU-109 based weapons. They all were laser guided. They hit penetrated reinforced concrete or steel blast doors. These were the GBU-10I, GBU-24 and GBU-27's. At the end of the war the GBU-28 ws used which had a modified GBU-27 guidance unit. Additionally the GBU-15/AGM-130 electro optical glide bombs had BLU-109 variants in addition to the MK-84 ones. It was the performance of the GBU-24's and '27's that lead to the development of the SBD. They discovered that these weapons would not only penetrate the roofs of the HAS's but also the floor before exploding. That's why they sized the SBD as they did to have enough energy to get thru the rood and then explode. There is no need to heave the floor if the explosion destroys the aircraft in the shelter. The key point is that they all had laser guidance packages which we still use today that did not interfere with penetration and proved to be highly effective.
During this time the F-111 and F-15E units were also plinking tanks using the blast fragmentation MK-82's with a laser guidance package creating what we know as a GBU-12. Once again this blast frag warhead with a laser guidance package consistently penetrated the armor on the tops of the turrets of Iraqi T-72's causing massive secondary's tossing the turret assemblies from the chassis. Once again no interference from the guidance package only this time the warheads weren't even penetrators. There is video and photos to support this.
Finally during the Falklands campaign of 1982 several British Frigates were damaged and or sunk using the MK-82 delivered using the MK-1 eyeball from Argentine A-4's. In this case there were reports of duds because the fuses with the arming vanes on their noses did not have enough turns to arm the weapon because of the close low altitude deliveries. This saved several ships but please note that the fuse pocket didn't have a nose plug because the fuse was in it. No different than the LGB's above.
So to summarize laser guidance packages based on actual combat experience don't impede penetration of US warheads.